A study led by the teams of Natalio Garbi and Christian Kurts at the IMMEI identifies cGAS/STING activation and IFN-I production by inflammatory macrophages as a driver of severe ANCA-associated autoimmune vasculitis. Genetic and pharmacological interventions blocking this pathway ameliorate disease and accelerate recovery, identifying potential targets for therapeutic intervention in patients. Great collaborative study within the DFG STBTRR237 Nucleic acid immunity consortium driven by students Nina Kessler and Susanne Viehmann.
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing.
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina Maria Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M.C. Böhner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. I. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Bahrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Rösen-Wolff, Lino Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi. Journal of Experimental Medicine doi.org/10.1084/jem.20220759