Stromal cell populations within secondary lymphoid organs (SLOs) guide immune cell migration and play a complex immunoregulatory role in an arising immune response. Stromal cells have emerged as a novel field in immunology and gained enormous interest during the last decade. It is increasingly evident that the immune response cannot be fully understood without the stromal aspect since the stromal network exhibit complex interactions and cross talks with immune cells necessary for immunity and tolerance. Importantly, these stromal circuits also operate outside of the SLOs such as within the tumor microenvironment.
The research aims to understand the immunoregulatory role of stromal cells during arising T cell responses, how this is affected by danger signals and how we can influence stromal-T cell cross-talk for a more efficient immune response within SLOs and in the tumor microenvironment.