Tim Rollenske Laboratory

Our body surfaces inhabit a myriad of microbes, our microbiota, which is composed of viruses, bacteria, archaea, and fungi. These commensal microorganisms live with us in a mutualistic relationship. At our mucosal body surfaces the density and diversity of the microbiota is one of the highest in the body. The Mucosal Immunology group is interested how B cells and their antibodies control this diverse microbiota and to protect from infection by pathogens at mucosal sites.

We use human samples and germ-free or gnotobiotic mouse models that possess a microbiota with defined composition of bacterial strains. These reductionist models allow us to address our questions at mechanistic and molecular detail. We pair those models with single cell B cell receptor repertoire analysis and monoclonal antibody testing to functionally define how the humoral immune system contributes to a mutualistic host-microbe relationship.

Our long-term goals are

1. to identify correlates of antibody-mediated protection in mucosal vaccination or infection
2. to improve mucosal vaccination strategies and
3. to identify and define the therapeutic potential of selected monoclonal antibodies to pathogenic bacteria.