Research Interests

Our body surfaces inhabit a myriad of microbes, our microbiota, which is composed of viruses, bacteria, archaea, and fungi. These commensal microorganisms live with us in a mutualistic relationship. At our mucosal body surfaces the density and diversity of the microbiota is one of the highest in the body. The Mucosal Immunology group is interested how B cells and their antibodies control this diverse microbiota and to protect from infection by pathogens at mucosal sites.

We use human samples and germ-free or gnotobiotic mouse models that possess a microbiota with defined composition of bacterial strains. These reductionist models allow us to address our questions at mechanistic and molecular detail. We pair those models with single cell B cell receptor repertoire analysis and monoclonal antibody testing to functionally define how the humoral immune system contributes to a mutualistic host-microbe relationship.

Our long-term goals are

  1. to identify correlates of antibody-mediated protection in mucosal vaccination or infection
  2. to improve mucosal vaccination strategies and
  3. to identify and define the therapeutic potential of selected monoclonal antibodies to pathogenic bacteria.

Grant support

  • Emmy Noether DFG Grant
  • Multidisciplinary Center for Infectious Diseases (University of Bern)
  • Excellence Cluster ImmunoSensation2

Group achievements

  • ImmunoSensation2 Seed Funding Prize (Tim Rollenske, 2023)
  • Fritz and Ursula Melchers prize of the German Society for Immunology (Tim Rollenske, 2022)


list of publications can be found here


Prof. Dr. Tim Rollenske

Tel.: +49 228 287 - 51012


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