We are always looking for talented and motivated scientists. Please send a short description of why you are interested in joining our team, a CV, and if possible the contact details of 2-3 references to one of our group leaders directly or reach out to the administrative team.
PhD position – Interplay between macrophages and sex hormones in autoimmunity (Garbi Lab)
The Institute of Molecular Medicine and Experimental Immunology (IMMEI) at the Medical Faculty of the University of Bonn invites applications for a
PhD position – Interplay between macrophages and sex hormones in autoimmunity (m/f/o)
Available immediately for three years with the possibility of extension
The successful candidate will join the Department of Cellular Immunology (Prof. Natalio Garbi) to investigate how sex hormones regulate macrophage function in an autoimmune setting. Our previous findings have identified opposing functions of different macrophage subpopulations in the progression of severe autoimmune vasculitis following aberrant nucleic acid immunity (Kessler et al, JExpMed 2022). The project extends on these and other on-going findings to mechanistically delineate how different macrophage populations and sex hormones interact during progression of autoimmune vasculitis by utilizing conventional and state-of-the-art technologies such as single-cell RNAseq, spectral multiparameter flow cytometry and confocal microscopy, lipidomics and proteomics. The overarching goal is to understand key cellular and molecular mechanisms driving severe disease to identify much needed targeted therapies for this disease.
We offer:
The medical faculty is a hub for internationally recognised immunological institutes and a major player of the Immunosensation2 cluster of excellence in Germany (www.immnosensation.com). The Department of Cellular Immunology has extensive experience on infection immunology and autoimmunity and is part of the IMMEI, which hosts about 50 staff members in 6 independent research
groups with over 30 scientists and PhD students. Within this environment, we offer:
Additional information:
Related work in the lab:bit.ly/JExpMed ; bit.ly/_BioRxiv ; bit.ly/VideoRoundUp ; bit.ly/3G1PG6j
Complete publication list: https://bit.ly/Garbi-PubMed
Lab homepage: www.immei.de
Immunology in Bonn: www.immunosensation.com
Your profile:
To apply:
please send a motivation letter, C.V. with degree certificates and grades, and contacts of two references in one single pdf file using code “vasculitis PhD” to Prof. Natalio Garbi (ngarbi(ad)uni-bonn.de).
Deadline is Nov. 30th, 2022.
The University of Bonn is a German University of Excellence since 2019 that is committed to affirmative action for diversity and equal opportunities for all. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act).
Postdoctoral fellow – Nucleic Acid Immunity and Autoimmunity (Garbi Lab)
The Institute of Molecular Medicine and Experimental Immunology (IMMEI) at the Medical Faculty of the University of Bonn invites applications for a
Postdoctoral fellow – Nucleic Acid Immunity and Autoimmunity (m/f/o)
Available immediately for two years with the possibility of extension
The successful candidate will join the Department of Cellular Immunology (Prof. Natalio Garbi) to investigate how sex hormones regulate macrophage function in an autoimmune setting. Our previous findings have identified opposing functions of different macrophage subpopulations in the progression of severe autoimmune vasculitis following aberrant nucleic acid immunity (Kessler et al, JExpMed 2022). The project extends on these and other on-going findings to mechanistically delineate how different macrophage populations and sex hormones interact during progression of autoimmune vasculitis by utilizing conventional and state-of-the-art technologies such as single-cell RNAseq, spectral multiparameter flow cytometry and confocal microscopy, lipidomics and proteomics. The overarching goal is to understand key cellular and molecular mechanisms driving severe disease to identify much needed targeted therapies for this disease.
We offer:
The medical faculty is a hub for internationally recognised immunological institutes and a major player of the Immunosensation2 cluster of excellence in Germany (www.immnosensation.com). The Department of Cellular Immunology has extensive experience on infection immunology and autoimmunity and is part of the IMMEI, which hosts about 50 staff members in 6 independent research
groups with over 30 scientists and PhD students. Within this environment, we offer:
Additional information:
Related work in the lab:bit.ly/JExpMed ; bit.ly/_BioRxiv ; bit.ly/VideoRoundUp ; bit.ly/3G1PG6j
Complete publication list:bit.ly/Garbi-PubMed
Lab homepage: www.immei.de
Immunology in Bonn: www.immunosensation.com
Your profile:
To apply:
please highlight your research background, expertise, and publications in the inquiry email and attach a single-file CV with the contacts of two references to Prof. Natalio Garbi (ngarbi(ad)uni-bonn.de). Deadline is Nov. 30th, 2022.
The University of Bonn is a German University of Excellence since 2019 that is committed to affirmative action for diversity and equal opportunities for all. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act).
Joint-PhD position with University of Melbourne "Understanding the biology of tumour infiltrating regulatory T cells" (Becker-Gotot Lab)
Joint PhD position in Immunology
This joint PhD position in the groups of Dr Janine Becker-Gotot in Bonn and of Dr Ajithkumar Vasanthakumar in Melbourne is embedded in the DFG-funded international graduate school 2168 (IRTG2168). The graduate school comprises 20 projects that jointly investigate myeloid immune cells and the induction of adaptive immunity in the context of infection, tumors and inflammation. Our students will perform the core of their 3-years PhD project in Bonn and spend 1 year in Melbourne, jointly supervised by internationally leading scientists from both universities. Upon successful completion, they will be awarded a joint PhD degree by the University of Bonn and the University of Melbourne.
This particular project focusses on Understanding the biology of tumour infiltrating regulatory T cells.
Regulatory T cells (Tregs) that express the transcription factor Foxp3 are critical to preserve immune homeostasis. They potently suppress self-reactive and inflammatory immune cells to prevent autoimmunity and tissue damage. However, in the context of cancer, they hinder protective immunosurveillance and anti-tumour immunity to promote tumour growth and metastasis. Given their essential role in immune homeostasis, innovations are needed to specifically target and neutralize Tregs in the tumour microenvironment without compromising self-tolerance.
Our project aims to discover the homeostatic mechanisms of tumour infiltrating/accumulating Tregs, using cutting-edge genomic technologies, novel pre-clinical models, flow cytometry and metabolic analyses. We also aim to explore the interaction between Tregs and tumours as well as tissues to explore potential molecular mechanisms that underpin checkpoint blockage failure in primary versus metastatic niches.
For further information and how to apply please visit the IRTG2168 website.
