Kidney resident MAIT17 cells suppress inflammatory myeloid cells in immune-mediated kidney disease

New publication in Nature Communications

A study by the team of Prof Christian Kurts in collaboration with colleagues from the University Medical Center Hamburg Eppendorf has discovered that Mucosal-associated invariant T (MAIT) cells contribute to the suppression of inflammatory myeloid cells in immune-mediated kidney disease. The study now published in Nature Communications identified with single-cell RNA sequencing a MAIT17 population with anti-inflammatory properties, which resides in the kidney and gets activated during crescentic glomerulonephritis (cGN). Transcriptomic profiling, interactome analyses and in vivo functional validation of the predicted pathways suggest interaction of MAIT17 cells with proinflammatory myeloid cell populations in the kidney via the CXCR6–CXCL16 axis, resulting in suppression of myeloid cell tissue destructive capacity.
The study proposes a protective role of CXCR6+ MAIT cells in immune-mediated kidney disease, implicating them as a potential target for anti-inflammatory therapies.

Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE:
Mucosal-Associated Invariant T Cells Contribute to Suppression of Inflammatory Myeloid Cells in Immune-Mediated Kidney Disease.

Nat. Commun.