Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease
IMMEI researchers show that accumulation of disease-driving renal mononuclear phagocytes (MNPs) during nephritis partially results from clonal in situ proliferation at sites of inflammation. Accumulation of MNPs is a prominent feature in nephritis and results from recruitment of circulating monocytes into the kidney. In their recent study published in Kidney International, Junping Yin et al. found that in addition to the recruitment of circulating monocytes, clonal in situ proliferation at sites of inflammation also contributes to MNP accumulation. This finding suggests that therapies aimed only at preventing the recruitment of circulating monocytes may be of limited effectiveness.
Publication:
Junping Yin, Qi Mei, Marco Prinz, Zeinab Abdullah, Ulf Panzer, Jian Li, Sibylle von Vietinghoff and Christian Kurts:
Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease.
Kidney International; https://doi.org/10.1016/j.kint.2023.04.031
